The story follows Joe (Cage), a down-on-his-luck truck driver haunted by the memory of his deceased wife and child. He meets Julie (Potente), a spiritually gifted woman who enlists Joe in a desperate effort to find the lost soul of her comatose daughter, Billie (Mitchell). But the spirit of Joe’s dead wife Mary proves stronger, possessing the young woman’s body and determined to settle her unfinished business with the living.
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An exploration of the United States of America’s war on drugs from multiple perspectives. For the new head of the Office of National Drug Control Policy, the war becomes personal when he discovers his well-educated daughter is abusing cocaine within their comfortable suburban home. In Mexico, a flawed, but noble policeman agrees to testify against a powerful general in league with a cartel, and in San Diego, a drug kingpin’s sheltered trophy wife must learn her husband’s ruthless business after he is arrested, endangering her luxurious lifestyle.